Aleksandra Pikula, MDVascular Neurologist · Lifestyle Medicine · Physician-Coach · Researcher · Writer

Women's brain health, at the turning point.

Why are women's brains vulnerable at midlife — and what can we actually do about it?

Professor of Medicine (Neurology), University of Toronto
Jay & Sari Sonshine Chair in Stroke Prevention & Cerebrovascular Brain Health
Founder, HER PRISM™

"Midlife is the window where vulnerability becomes wisdom."

— Aleksandra Pikula, MD

Everything I do — one centre.

Six surfaces, one through-line: women's brain health.

110+peer-reviewed papers
$18M+research funding
20+years in vascular neurology
10+years in women's brain health
3+years in physician coaching

Selected research.

Midlife is the decisive, modifiable window for women's brain health — where vascular risk, the menopause transition, and lifestyle converge to shape lifelong stroke and dementia risk.

Click a title to read the paper ↗

Full CV & publicationsAll publications (NCBI)

Up to 80% of strokes and 45% of dementia are preventable.

The midlife years are our best chance to change that trajectory — for women most of all.

Collaborators & partners.

Working across institutions on women's brain health, stroke and dementia prevention.

THETA Heart & Stroke Foundation UK Biobank ACLM Global Brain Care Coalition Brain Care Labs (BCS) INSIGHT PAVING the Path to Wellness March of Dimes Canada UHN PiPER CIHR OSSU–SPOR WSO-GENESIS B+HARI ELMO UHN Women's Health Program U of T Department of Medicine

See the full team & collaborators

Speaking.

Keynotes and workshops on women's brain health, the midlife transition, and physician burnout.

Click any title to open its outline ↓

🧭From Depletion to Bio-Harmony: Brain Health & Burnout in Women in Medicine Keynote · women in medicine · physician wellbeing
  • The convergence of four perspectives on one question — as scientist, clinician, woman in medicine, and physician-coach
  • What happens to women's brain health when chronic stress in medicine meets the menopause transition
  • How midlife depletion reshapes both personal and professional life and outcomes
  • Bio-Harmony as the ultimate way forward — developed through self-healing and with others
  • The HER PRISM framework — a structured way back from depletion
🧠The Convergence Window — Burnout, Perimenopause & the Midlife Brain in Women Physicians Women in medicine · physician wellbeing
  • Why burnout, perimenopause, and cerebrovascular risk converge in midlife
  • The biology beneath "resilience" — HPA axis, sleep architecture, estrogen withdrawal
  • What the evidence shows about stroke and dementia risk in this window
  • Individualized levers — sequencing, not a checklist
🌿The Midlife Brain — Every Woman's Guide to Stroke & Dementia Prevention General public · women's-health & longevity audiences
  • Midlife as the critical, modifiable window for women's brain health
  • The vascular roots of cognitive aging — the brain as a vascular organ
  • The lifestyle pillars and how they work together
  • What every woman can start doing now
🔬Why Women's Brain Health Has Been Understudied — and What the Evidence Now Shows Scientific & clinical conferences
  • The historical research gap in women's neurology
  • Sex differences in stroke, dementia, and the menopause transition
  • The new evidence reshaping prevention
  • Where the field must go next
💼The Brain at Work — Cognitive Capital & Retaining Midlife Talent Corporate & organizational leadership
  • Cognitive capital as an organizational asset
  • Why midlife women are a high-value, at-risk segment of the workforce
  • Organization-led vs individual-led wellbeing — the 80/20
  • Practical workplace levers for brain health
🧭Bio-Harmony — A Framework for Sustainable Leadership in Medicine Executives, academic chairs & healthcare leaders
  • The Bio-Harmony framework — biology, values, systems, integration
  • Leading without depleting the nervous system
  • Building a sustainable practice and culture
  • From individual recovery to system change
From Vulnerability to Wisdom — A Vascular Neurologist's Sabbatical Keynote · fireside · TED-style
  • The personal story behind the science
  • What stepping back revealed about burnout and recovery
  • Translating lived experience into a framework
  • The window where vulnerability becomes wisdom

Two engagements confirmed for Fall 2026.

Inquire about speaking

Through HER Prism.

Long-form essays and notes on women's brain health and the lived experience of being a woman in medicine — on Substack, with a companion newsletter on LinkedIn.

Read on Substack   LinkedIn newsletter

Through HER Prism on Substack

Get in touch.

Speaking, media, and research collaboration. For coaching, visit herprism.co.